dopamine neuron stimulating actions of a gdnf propeptide多巴胺神经元gdnf前肽的刺激行动.pdfVIP

Dopamine Neuron Stimulating Actions of a GDNF Propeptide 1,2 1 1 1 1 Luke H. Bradley *, Josh Fuqua , April Richardson , Jadwiga Turchan-Cholewo , Yi Ai , Kristen A. 1 3 1 1 1 1 Kelps , John D. Glass , Xiuquan He , Zhiming Zhang , Richard Grondin , O. Meagan Littrell , Peter 1 1 1 1 Huettl , Francois Pomerleau , Don M. Gash , Greg A. Gerhardt 1 Department of Anatomy Neurobiology and the Morris K. Udall Parkinson’s Disease Research Center of Excellence, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America, 2 Department of Molecular Cellular Biochemistry and the Center of Structural Biology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America, 3 Shoreham, New York, United States of America Abstract Background: Neurotrophic factors, such as glial cell line-derived neurotrophic factor (GDNF), have shown great promise for protection and restoration of damaged or dying dopamine neurons in animal models and in some Parkinson’s disease (PD) clinical trials. However, the delivery of neurotrophic factors to the brain is difficult due to their large size and poor bio-distribution. In addition, developing more efficacious trophic factors is hampered by the difficulty of synthesis and structural modification. Small molecules with neurotrophic actions that are easy to synthesize and modify to improve bioavailability are needed. Methods and Findings: Here we present the neurobiological actions of dopamine neuron stimulatin