dopamine regulates angiogenesis in normal dermal wound tissues多巴胺调节血管生成在正常皮肤伤口组织.pdfVIP

Dopamine Regulates Angiogenesis in Normal Dermal Wound Tissues 1 1 1 1 1 Saurav Shome , Tapasi Rana , Subhalakshmi Ganguly , Biswarup Basu , Sandipan Chaki Choudhury , 2 2 1 2,3,4 Chandrani Sarkar , Debanjan Chakroborty , Partha Sarathi Dasgupta *, Sujit Basu * 1 Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India, 2 Department of Pathology, Ohio State University, Columbus, Ohio, United States of America, 3 Dorthy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio, United States of America, 4 Arthur G. James Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America Abstract Cutaneous wound healing is a normal physiological process and comprises different phases. Among these phases, angiogenesis or new blood vessel formation in wound tissue plays an important role. Skin is richly supplied by sympathetic nerves and evidences indicate the significant role of the sympathetic nervous system in cutaneous wound healing. Dopamine (DA) is an important catecholamine neurotransmitter released by the sympathetic nerve endings and recent studies have demonstrated the potent anti-angiogenic action of DA, which is mediated through its D2 DA receptors. We therefore postulate that this endogenous catecholamine neurotransmitter may have a role in the neovascularization of dermal wound tissues and subsequently in the proc