down-regulation of the interferon signaling pathway in t lymphocytes from patients with metastatic melanoma下调t淋巴细胞的干扰素信号通路从转移性黑色素瘤患者.pdfVIP

PLoS MEDICINE Down-Regulation of the Interferon Signaling Pathway in T Lymphocytes from Patients with Metastatic Melanoma 1 1,2 2 3 2 1* Rebecca J. Critchley-Thorne , Ning Yan , Serban Nacu , Jeffrey Weber , Susan P. Holmes , Peter P. Lee 1 Division of Hematology, Department of Medicine, Stanford University, Stanford, California, United States of America, 2 Department of Statistics, Stanford University, Stanford, California, United States of America, 3 Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America Funding: This work was supported A B S T R A C T by NIH R01 CA 090809 (PL). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the Background manuscript. Dysfunction of the immune system has been documented in many types of cancers. The Competing Interests: The authors precise nature and molecular basis of immune dysfunction in the cancer state are not well have declared that no competing defined. interests exist. Academic Editor: Franco M. Marincola, National Institutes of Methods and Findings Health, United States of America To gain insights into the molecular mechanisms of immune dysfunction in cancer, gene Citation: Critchley-Thorne RJ, Yan N, expression profiles of pure sorted peripheral blood lymphocytes from 12 patients with Nacu S, Weber J, Holmes SP, et al. (2007) Down-regulation of the