early-life stress is associated with gender-based vulnerability to epileptogenesis in rat pups时艰难的生活压力与性别脆弱性epileptogenesis老鼠幼崽.pdfVIP

Early-Life Stress Is Associated with Gender-Based Vulnerability to Epileptogenesis in Rat Pups ´ 1,2 1 1 1 ´ 1 Sebastien Desgent *, Sandra Duss , Nathalie T. Sanon , Pablo Lema , Maxime Levesque , ´ 1 ´ 1 1 ` 1,2 1,2 David Hebert , Rose-Marie Rebillard , Karine Bibeau , Michele Brochu , Lionel Carmant * ´ ´ ´ ´ ´ ´ 1 Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Universite de Montreal, Montreal, Quebec, Canada, 2 Departement de Physiologie, Faculte de ´ ´ ´ ´ ´ Medecine, Universite de Montreal, Montreal, Quebec, Canada Abstract During development, the risk of developing mesial temporal lobe epilepsy (MTLE) increases when the developing brain is exposed to more than one insult in early life. Early life insults include abnormalities of cortical development, hypoxic- ischemic injury and prolonged febrile seizures. To study epileptogenesis, we have developed a two-hit model of MTLE characterized by two early-life insults: a freeze lesion-induced cortical malformation at post-natal day 1 (P1), and a prolonged hyperthermic seizure (HS) at P10. As early life stressors lead to sexual dimorphism in both acute response and long-term outcome, we hypothesized that our model