eicosanoid release is increased by membrane destabilization and cftr inhibition in calu-3 cells类二十烷酸释放增加了膜不稳定和雌性生殖道抑制calu-3细胞.pdfVIP

Eicosanoid Release Is Increased by Membrane Destabilization and CFTR Inhibition in Calu-3 Cells 1 1. 2. 1 1 1 Florence Borot , Diane-Lore Vieu , Grazyna Faure , Janine Fritsch , Julien Colas , Sandra Moriceau , 1 1 3 4 Maryvonne Baudouin-Legros , Franck Brouillard , Jesus Ayala-Sanmartin , Lhousseine Touqui , Marc 5 1 1 Chanson , Aleksander Edelman , Mario Ollero * ´ ´ ´ ´ 1 INSERM, U845, Universite Paris Descartes, Faculte de Medecine Paris Descartes, Paris, France, 2 Institut Pasteur, Unite d’Immunologie Structurale, CNRS, URA 2185, Paris, ´ ´ ´ ´ ´ France, 3 CNRS, UMR7203, Groupe N. J. Conte, Laboratoire des BioMolecules, Paris, France, 4 Institut Pasteur, Unite de Defense Innee et Inflammation, INSERM, U874, Paris, ˆ ´ ´ ` France, 5 Laboratoire d’Investigation Clinique III, Hopitaux Universitaires et Faculte de Medecine, Geneve, Switzerland Abstract The antiinflammatory protein annexin-1 (ANXA1) and the adaptor S100A10 (p11), inhibit cytosolic phospholipase A2 (cPLA2a) by direct interaction. Since the latter is responsible for the cleavage of arachidonic acid at membrane phospholipids, all th