elk1 uses different dna binding modes to regulate functionally distinct classes of target geneselk1使用不同的dna结合模式调节目标基因的功能不同的类.pdfVIP

ELK1 Uses Different DNA Binding Modes to Regulate Functionally Distinct Classes of Target Genes Zaneta Odrowaz, Andrew D. Sharrocks* Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom Abstract Eukaryotic transcription factors are grouped into families and, due to their similar DNA binding domains, often have the potential to bind to the same genomic regions. This can lead to redundancy at the level of DNA binding, and mechanisms are required to generate specific functional outcomes that enable distinct gene expression programmes to be con