effect of different doses of aerobic exercise on total white blood cell (wbc) and wbc subfraction number in postmenopausal women results from drew不同剂量的有氧运动对总白细胞(wbc)和白细胞小分支数量在绝经后妇女的结果了.pdfVIP

Effect of Different Doses of Aerobic Exercise on Total White Blood Cell (WBC) and WBC Subfraction Number in Postmenopausal Women: Results from DREW 1 1 2 3 1 Neil M. Johannsen *, Damon L. Swift , William D. Johnson , Vishwa D. Dixit , Conrad P. Earnest , Steven N. Blair4, Timothy S. Church1 1 Department of Preventive Medicine, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America, 2 Department of Biostatistics, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America, 3 Immunobiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America, 4 Department of Exercise Science and Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina, United States of America Abstract Background: Elevated total white blood cell (WBC) count is associated with an increased risk of coronary heart disease and death. Aerobic exercise is associated with lower total WBC, neutrophil, and monocyte counts. However, no studies have evaluated the effect of the amount of aerobic exercise (dose) on total WBC and WBC subfraction counts. Purpose: To examine the effects of 3 different doses of aerobic exercise on changes in total WBC and WBC subfraction counts and independent effects of changes in fitness, adiposity, markers of inflammation (IL-6, TNF-a, C-reactive protein), fasting glucose metabolism, and adiponectin. Methods: Data from 390 sedentary, overweight/obese postmenopausal women from the DREW study were used in these analyses. Women were randomized to a non-exercise control group or one of 3 exercise groups: energy expenditure of 4, 8, or 12 kcal kg21?week21 (KKW) for 6 months at an intensity of 50% VO2peak.