histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma富含组氨酸糖蛋白可以防止老鼠实验胶质母细胞瘤的发展.pdfVIP
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histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma富含组氨酸糖蛋白可以防止老鼠实验胶质母细胞瘤的发展
Histidine-Rich Glycoprotein Can Prevent Development of
Mouse Experimental Glioblastoma
¨ 1. 1. 2 1 3
Maria Karrlander , Nanna Lindberg , Tommie Olofsson , Marianne Kastemar , Anna-Karin Olsson ,
Lene Uhrbom1*
1 Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden, 2 The National Board of Forensic Medicine, Department of Forensic Medicine, Uppsala,
Sweden, 3 Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Abstract
Extensive angiogenesis, formation of new capillaries from pre-existing blood vessels, is an important feature of malignant
glioma. Several antiangiogenic drugs targeting vascular endothelial growth factor (VEGF) or its receptors are currently in
clinical trials as therapy for high-grade glioma and bevacizumab was recently approved by the FDA for treatment of
recurrent glioblastoma. However, the modest efficacy of these drugs and emerging problems with anti-VEGF treatment
resistance welcome the development of alternative antiangiogenic therapies. One potential candidate is histidine-rich
glycoprotein (HRG), a plasma protein with antiangiogenic properties that can inhibit endothelial cell adhesion and
migration. We have used the RCAS/TV-A mouse model for gliomas to investigate the effect of HRG on brain tumor
development. Tumors were induced with platelet-derived growth factor-B (PDGF-B), in the presence or absence of HRG. We
found that HRG had little effect on tumor incidence but could significantly inhibit the development of malignant glioma
and completely prevent the occurrence of grade IV tumors (glioblastoma).
¨
Citation: Kar
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