histone h2a c-terminus regulates chromatin dynamics, remodeling, and histone h1 binding组蛋白h2a糖调节染色质动力学、重构和组蛋白h1绑定.pdfVIP
- 1、本文档共12页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
histone h2a c-terminus regulates chromatin dynamics, remodeling, and histone h1 binding组蛋白h2a糖调节染色质动力学、重构和组蛋白h1绑定
Histone H2A C-Terminus Regulates Chromatin Dynamics,
Remodeling, and Histone H1 Binding
1. 2. 1¤ 3 1 1
Christine Vogler , Claudia Huber , Tanja Waldmann , Ramona Ettig , Lora Braun , Annalisa Izzo ,
1 1 4 4
Sylvain Daujat , Isabelle Chassignet , Andres Joaquin Lopez-Contreras , Oscar Fernandez-Capetillo ,
5 3 ¨ 2 1
Miroslav Dundr , Karsten Rippe , Gernot Langst *, Robert Schneider *
1 Max-Planck Institute of Immunobiology, Freiburg, Germany, 2 Biochemie III, University of Regensburg, Regensburg, Germany, 3 German Cancer Research Center (DKFZ)
and BioQuant, Research Group Genome Organization and Function, Heidelberg, Germany, 4 Genomic Instability Group, Spanish National Cancer Research Centre, Madrid,
Spain, 5 Rosalind Franklin University, North Chicago, Illinois, United States of America
Abstract
The tails of histone proteins are central players for all chromatin-mediated processes. Whereas the N-terminal histone tails
have been studied extensively, little is known about the function of the H2A C-terminus. Here, we show that the H2A C-
terminal tail plays a pivotal role in regulating chromatin structure and dynamics. We find that cells expressing C-terminally
truncated H2A show increased stress sensitivity. Moreover, both the complete and the partial deletion of the tail result in
increased histone exchange kinetics and nucleosome mobility in vivo and in vitro. Importantly, our experiments reveal that
the H2A C-terminus is required for efficient nucleosome transloc
您可能关注的文档
- head lice surveillance on a deregulated otc-sales market a study using web query data头虱监测在管制otc-sales市场研究使用web查询数据.pdf
- hcv tumor promoting effect is dependent on host genetic background丙肝病毒肿瘤促进作用依赖于宿主遗传背景.pdf
- health and human rights in chin state, western burma a population-based assessment using multistaged household cluster sampling健康和人权在下巴,西方缅甸以人群为基础的评估使用多级式家庭整群抽样.pdf
- head circumference of infants born to mothers with different educational levels; the generation r study头围的不同教育水平的母亲产下的婴儿;.pdf
- health care burden and cost associated with fetal alcohol syndrome based on official canadian data与胎儿酒精综合症相关医疗负担和成本基于加拿大官方数据.pdf
- health behaviours, socioeconomic status, and mortality further analyses of the british whitehall ii and the french gazel prospective cohorts健康行为、社会经济地位和死亡率进一步分析英国白厅二世和法国瞪羚的潜在人群.pdf
- health centre surveys as a potential tool for monitoring malaria epidemiology by area and over time健康中心作为一个潜在的工具来监控疟疾流行病学调查的地区,随着时间的推移.pdf
- health development versus medical relief not a turf battle卫生发展与医疗救助不是一个地盘的战斗.pdf
- health development versus medical relief the illusion of aid卫生发展与医疗救助援助的假象.pdf
- health diplomacy and the enduring relevance of foreign policy interests卫生外交和持久的外交政策利益的重要性.pdf
文档评论(0)