nt-probnp and circulating inflammation markers in prediction of a normal myocardial scintigraphy in patients with symptoms of coronary artery disease中位数水平以上病人和循环炎症标记物预测正常心肌显像的患者的冠状动脉疾病的症状.pdfVIP

NT-proBNP and Circulating Inflammation Markers in Prediction of a Normal Myocardial Scintigraphy in Patients with Symptoms of Coronary Artery Disease 1 2 3 4 1,5 Camilla Noelle Rathcke *, Erik Kjøller , Niels Fogh-Andersen , Bo Zerahn , Henrik Vestergaard 1 Department of Internal Medicine, Center of Endocrinology and Metabolism, Copenhagen University Hospital Herlev, Herlev, Denmark, 2 Department of Cardiology, Copenhagen University Hospital Herlev, Herlev, Denmark, 3 Department of Clinical Biochemistry, Copenhagen University Hospital Herlev, Herlev, Denmark, 4 Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Herlev, Herlev, Denmark, 5 Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark Abstract Background: Myocardial perfusion imaging (MPI) can detect myocardial perfusion abnormalities but many examinations are without pathological findings. This study examines whether circulating biomarkers can be used as screening modality prior to MPI. Methodology/Principal Findings: 243 patients with an intermediate risk of CAD or with known CAD with renewed suspicion of ischemia were referred to MPI. Blood samples were analyzed for N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP), YKL-40, IL-6, matrix metalloproteinase 9 (MMP-9) and high sensitive C-reactive protein (hsCRP). Patients with myocardial perfusion defects had elevated levels of NT-proBNP (p,0.0001), YKL-40 (p = 0.03) and IL-6 (p = 0.03) but not of hsCRP (p = 0.58) nor of MMP-9 (p = 0.14). The NT-proBNP increase was observed in both genders (p,0.0001), whereas YKL-40 (p = 0.005) and IL-6 (p = 0.02) were elevated only in men. A NT-pro