role of neuropoietic cytokines in development and progression of diabetic polyneuropathy from glucose metabolism to neurodegenerationneuropoietic细胞因子在糖尿病的发展和恶化多神经病葡萄糖代谢、神经退化.pdfVIP

Experimental Diab. Res., 4:303–312, 2003 c Copyright Taylor and Francis Inc. ISSN: 1543-8600 print / 1543-8619 online DOI: 10.1080/15438600390249736 Role of Neuropoietic Cytokines in Development and Progression of Diabetic Polyneuropathy: From Glucose Metabolism to Neurodegeneration Dusanka S. Skundric and Robert P. Lisak Department of Neurology, Division of Neuroimmunology, and Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit Medical Centre, Detroit, Michigan, USA regeneration may potentially be utilized for the prevention Diabetic neuropathy develops as a result of hyper- and/or therapy of diabetic neuropathy. glycemia-induced local metabolic and microvascular changes in both type I and type II diabetes mellitus. Diabetic Keywords Cytokines; Diabetic Neuropathy; Schwann Cell neuropathy shows slower impulse conduction, axonal de- generation, and impaired regeneration. Diabetic neuropa- thy affects peripheral, central, and visceral sensorimotor and motor nerves, causing improper locomotor and vis- INTRODUCTION ceral organ dysfunctions. The pathogenesis of diabetic neu- Diabetic polyneuropathy is a chronic complication of both ropathy is complex and involves multiple pathways. Lack type I and type II diabetes mellitus. It affects peripheral, cen- of success in preventing neuropathy, even with successful tral, and visceral sensorimotor and motor nerves. Diabetic neu- treatment of hyperglycemia, suggests the presence of early mediators between hyperglycemia-induced metabolic and ropathy develops as a result of hyperglycemia-induced local enzymatic changes and functional and structural pr