sequence variation and expression of the gimap gene family in the bb rat序列变化和表达gimap基因家族的bb老鼠.pdfVIP

Hindawi Publishing Corporation Experimental Diabetes Research Volume 2009, Article ID 835650, 10 pages doi:10.1155/2009/835650 Research Article Sequence Variation and Expression of the Gimap Gene Family in the BB Rat Elizabeth A. Rutledge,1, 2 Jessica M. Fuller,3, 4 Brian Van Yserloo,1 Daniel H. Moralejo,5 Ruth A. Ettinger,4 Prashant Gaur,1 Jana L. Hoehna,1 Morgan R. Peterson,1 1 6 ˚ 3, 4 Richard Jensen, Anne E. Kwitek, and Ake Lernmark 1 Diabetes and Endocrinology Research Center, University of Washington, 815 Mercer Street, Building A, S130, Seattle, WA 98109, USA 2 Department of Biological and Chemical Sciences, Salish Kootenai College, 58138 Hwy 93, Pablo, P.O. Box 70, MT 59855, USA 3 Department of Clinical Sciences, Clinical Research Center, Lund University, Entrance 72, Building 91:10, 20502 Malmo, Sweden ¨ 4 Department of Medicine, University of Washington, 1959 N.E. Pacific Street, Seattle, P.O. Box 357710, WA 98195, USA 5 Department of Comparative Medicine, University of Washington, 1959 N.E. Pacific Street, Seattle, P.O. Box 357190, WA 98195, USA 6 Department of Internal Medicine, University of Iowa, 375 Newton Road, 3111B MERF, Iowa City, IA 52242, USA Correspondence should be addressed to Jessica M. Fuller, jfuller@ Received 9 December 2008; Accepted 8 February 2009 Recommended by Anjan Kowluru Positional cloning of lymphopenia (lyp) in the BB rat revealed a frameshift mutation in Gimap5, a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. Our aim was to clone and sequen