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Hindawi Publishing Corporation Sarcoma Volume 2011, Article ID 984340, 7 pages doi:10.1155/2011/984340 Clinical Study Sequential Dose-Dense Doxorubicin and Ifosfamide in Advanced Soft-Tissue Sarcoma Patients in an Out-Patient-Basis Schedule G. F. G. Almeida,1, 2 G. Castro Jr.,1 I. M. L. Snitcovsky,1 S. A. Siqueira,3 E. H. Akaishi,4 O. P. Camargo,5 C. R. G. C. M. Oliveira,6 and M. H. H. Federico1 1 Servico de Oncologia Clinica, Instituto de Radiologia, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, 05403-900 Sao Paulo, SP, Brazil 2 Centro de Hematologia e Oncologia—CEHON, Avenida Araujo Pinho, 439 Canela, 40110-150 Salvador, BA, Brazil 3 Servico de Anatomia Patologica, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, 05403-010 Sao Paulo, SP, Brazil 4 Terceira Clinica Cirurgica, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, 05403-010 Sao Paulo, SP, Brazil 5 Instituto de Ortopedia e Traumatologia, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, 05403-010 Sao Paulo, SP, Brazil 6 Laboratorio de Anatomia Patologica, Instituto de Ortopedia e Traumatologia, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, 05403-010 Sao Paulo, SP, Brazil Correspondence should be addressed to G. F. G. Almeida, gustavofgalmeida@.br Received 8 August 2010; Revised 5 April 2011; Accepted 4 May 2011 Academic Editor: R. Pollock Copyright © 2011 G. F. G. Almeida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Aims . This phase II study