signaling mechanisms in the regulation of renal matrix metabolism in diabetes信号机制在糖尿病肾矩阵的调节新陈代谢.pdfVIP

Hindawi Publishing Corporation Experimental Diabetes Research Volume 2012, Article ID 749812, 10 pages doi:10.1155/2012/749812 Review Article Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes Meenalakshmi M. Mariappan Division of Nephrology, Department of Medicine, MC7882, South Texas Veterans Healthcare System, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA Correspondence should be addressed to Meenalakshmi M. Mariappan, malini@ Received 5 August 2011; Accepted 2 November 2011 Academic Editor: Theodore W. Kurtz Copyright © 2012 Meenalakshmi M. Mariappan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Renal hypertrophy and accumulation of extracellular matrix proteins are among cardinal manifestations of diabetic nephropathy. TGF beta system has been implicated in the pathogenesis of these manifestations. Among signaling pathways activated in the kidney in diabetes, mTOR- (mammalian target of rapamycin-)regulated pathways are pivotal in orchestrating high glucose- induced production of ECM proteins leading to functional and structural changes in the kidney culminating in adverse outcomes. Understanding signaling pathways that influence individual matrix protein expression could lead to the development of new interventional strategies. This paper will highlight some of the diverse components of the signaling network stimulated by hyperglycemia with an emphasis on extracellular matrix protein metabolism in the kidney in diabetes. 1. Introduction