surface-enhanced oxidation and determination of isothipendyl hydrochloride at an electrochemical sensing film constructed by multiwalled carbon nanotubes表面增强氧化和决心isothipendyl盐酸盐的电化学传感膜由微碳纳米管.pdfVIP

Hindawi Publishing Corporation International Journal of Electrochemistry Volume 2012, Article ID 875631, 6 pages doi:10.1155/2012/875631 Research Article Surface-Enhanced Oxidation and Determination of Isothipendyl Hydrochloride at an Electrochemical Sensing Film Constructed by Multiwalled Carbon Nanotubes S. N. Prashanth, Shankara S. Kalanur, Nagappa L. Teradal, and J. Seetharamappa Department of Chemistry, Karnatak University, Dharwad 580 003, India Correspondence should be addressed to J. Seetharamappa, j seetharamappa@rediff Received 20 May 2011; Revised 15 October 2011; Accepted 27 October 2011 ´ Academic Editor: Benjamın R. Scharifker Copyright © 2012 S. N. Prashanth et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The electrochemical behavior of isothipendyl hydrochloride (IPH) was investigated at bare and multiwalled-carbon-nanotube modified glassy carbon electrode (MWCNT-GCE). IPH (55 μM) showed two oxidation peaks in Britton-Robinson (BR) buffer of pH 7.0. The oxidation process of IPH was observed to be irreversible over the pH range of 2.5–9.0. The influence of pH, scan rate, and concentration of the drug on anodic peak was studied. A differential pulse voltammetric method with good precision and accuracy was developed for the determination of IPH in pure and biological fluids. The peak current was found to be linearly de- pendent on the concentration of IPH in the range of 1.25–55 μM. The values of limit of detection and limit of quantification were noticed to be 0.284 and 0.949 μM, respectively. 1. Introduction