sopungyangjae-tang inhibits development of dermatitis in ncnga micesopungyangjae-tang抑制皮炎发展ncnga老鼠.pdfVIP

Advance Access Publication 12 March 2007 eCAM 2008;5(2)173–180 doi:10.1093/ecam/nem015 Original Article Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice 1 2 3 4 1 Yuba Raj Pokharel , Sung Chul Lim , Sang Chan Kim , Tae-Hwe Heo , Hoo Kyun Choi and Keon Wook Kang1 1BK21 Project Team, College of Pharmacy and 2Department of Pathology, College of Medicine, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759, 3Department of Prescription, College of Oriental Medicine, Daegu Haany University, Daegu 706-060 and 4College of Biomedical Laboratory Science, Konyang University, Daejeon, South Korea Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SYT inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-a (TNF