surgical and pathological characteristics of papillary thyroid cancer in children and adolescents乳头状甲状腺癌的手术和病理特征儿童和青少年.pdfVIP

Hindawi Publishing Corporation International Journal of Pediatrics Volume 2012, Article ID 125389, 6 pages doi:10.1155/2012/125389 Research Article Surgical and Pathological Characteristics of Papillary Thyroid Cancer in Children and Adolescents Davor Dzepina Department of ENT—Head and Neck Surgery, Sisters of Charity University Hospital, Vinogradska 29, 10000 Zagreb, Croatia Correspondence should be addressed to Davor Dzepina, dzepina.davor@ Received 14 June 2011; Revised 8 September 2011; Accepted 22 September 2011 Academic Editor: Tomislav Baudoin Copyright © 2012 Davor Dzepina. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Thyroid carcinoma is a relatively rare pediatric pathology, comprising around 3% of all childhood tumors. We investigated parameters of tumor aggressiveness, multicentricity, and locoregional metastatic spread patterns in patients up to 18 years of age and made comparison with the older group. All patients were operated upon with total thyroidectomy, with or without lymph-node neck dissection. Results. Patients with papillary carcinoma present with more advanced stage, larger primary tumor, and more commonly present with palpable thyroid and/or neck node. Overall, papillary cancer demonstrated pathological aggressiveness as defined by our criteria in 60%, multicentricity in 40%, and locoregional metastatic foci in 77% of cases. Multicentric tumor foci in both thyroid lobes and tumor aggressiveness were identified as a risk factor for metastatic development. Conclusion. By observing clinicopathological parameters, we demonstrated that papillary thyroid can