the correlation between microsatellite instability and the features of sporadic colorectal cancer in the north part of iran微卫星不稳定和零星的特征之间的相关性大肠癌伊朗北部的一部分.pdfVIP

Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2012, Article ID 756263, 6 pages doi:10.1155/2012/756263 Clinical Study The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran Masoumeh Faghani,1 Saba Fakhrieh Asl,2 Fariborz Mansour-Ghanaei,2 Keyvan Aminian,2 Alireza Tarang,3 Ramin Seighalani,3 and Azadeh Javadi3 1 Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran 2 Gastrointestinal and Liver Diseases Research Center (GLDRC), Razi Hospital, Guilan University of Medical Sciences, Sardar-Jangle Avenue, P.O. Box 41448-95655, Rasht, Iran 3 Genomics Animal Department, Agricultural Biotechnology Research Institute of North Region, Rasht, Iran Correspondence should be addressed to Saba Fakhrieh Asl, sfakhrieh@ and Fariborz Mansour-Ghanaei, ghanaie@ Received 15 May 2012; Revised 9 September 2012; Accepted 14 October 2012 Academic Editor: Akira Andoh Copyright © 2012 Masoumeh Faghani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran. Materials and Methods. A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied. No patients had positive family history of cancers. The frequencies of MSI were analyzed by testing the BAT-26 and BAT-25 markers. Results. MSI analysis revealed that 22.9% of the tumors (22 patients) were microsatellite instabilit