the effect of alternating current iontophoresis on rats with the chronic constriction injury to the infraorbital nerve交流电电离子透入疗法的效果在大鼠慢性收缩损伤眼眶下的神经.pdfVIP

Hindawi Publishing Corporation International Journal of Dentistry Volume 2012, Article ID 405292, 7 pages doi:10.1155/2012/405292 Review Article The Effect of Alternating Current Iontophoresis on Rats with the Chronic Constriction Injury to the Infraorbital Nerve Yoko Yamazaki,1 Masahiro Umino,2 Haruhisa Fukayama,3 and Masahiko Shimada1 1 Department of Orofacial Pain Management, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan 2 TTI ellebeau, Inc., Shinkan Building, Higashi-shinagawa, Shinagawa-ku, Tokyo 140-0002, Japan 3 Department of Anesthesiology and Clinical Physiology, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan Correspondence should be addressed to Yoko Yamazaki, yamazaki-yo.ofpm@tmd.ac.jp Received 16 December 2011; Revised 7 March 2012; Accepted 20 March 2012 Academic Editor: Yuzuru Kaneko Copyright © 2012 Yoko Yamazaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This study aimed to examine the effect of AC iontophoresis on rats with the chronic constriction injury (CCI) to the infraorbital nerve by animal experiments. CCI model rats were divided into four groups, namely, rats that received general anesthesia for 60 min except AC IOP (CCI: n = 5), AC IOP with 0.9% physiological saline for 60 min (CCI + saline AC IOP: n = 5), AC IOP with 4% lidocaine hydrochloride for 60 min (CCI + lidocaine AC IOP: n = 5), and attachment of two electrodes soaked with 4% lidocaine hydrochloride to the facial skin for 60 min (CCI + attach lidocaine: n = 5). In the CCI + lidocaine AC IOP group, an elevated withdrawal threshold