the plant extracts of momordica charantia and trigonella foenum graecum have antioxidant and anti-hyperglycemic properties for cardiac tissue during diabetes mellitus苦瓜的植物提取物和生长foenum graecum有抗氧化和anti-hyperglycemic属性在糖尿病心脏组织.pdfVIP

ReseaRCh papeR Oxidative Medicine and Cellular Longevity 2:5, 290-296; November/December 2009; © 2009 Landes Bioscience The plant extracts of Momordica charantia and Trigonella foenum graecum have antioxidant and anti-hyperglycemic properties for cardiac tissue during diabetes mellitus Uma Nath Tripathi and Deepak Chandra* Department of Biochemistry; University of Lucknow; Lucknow, India Key words: Alloxan, diabetic rat, heart, antioxidant status, lipid peroxidation, Momordica charantia , Trigonella foenum graecum Abbreviations: AGEs, advanced glycation end product; AR, aldose reductase; CAT, catalase; CDNB, 1-chloro-2, 4-dinitrobenzene; CVD, cardiovascular disease; DM, diabetes mellitus; DTNB, 5,5’-Dithio-bis 2-nitrobenzoic acid; EDTA, ethylene diamine tetra acetic acid; FBG, fasting blood glucose; GPx, glutathione peroxidase; GSH, reduced glutathione; GST, glutathione-s-transferase; LPO, lipid peroxidation; MC, Momordica charantia ; MDA, malondialdehyde; NADPH, nicotinamide adenine dinucleotide phosphate (reduced); ROS, reactive oxygen species; SOD, superoxide dismutase; TBARS, thiobarbituric acid reactive substances; TEP, 1, 1, 3, 3 tetraethoxypropane; TFG, Trigonella foenum graecum Oxidative stress is currently suggested to play a major role in the development of diabetes mellitus. There is an increas- ing demand of natural anti-diabetic agents, as continuous administration of existing drugs and insulin are associated with many side effects and toxicity. The present study was aimed to investigate the effect of Momordica charantia (MC) and Trigonella foenum graecum (TFG) extracts (aqueous) on antioxidant status and lipid peroxidation in heart tissue of normal and