the potential utility of curcumin in the treatment of her-2-overexpressed breast cancer an in vitro and in vivo comparison study with herceptin姜黄素治疗的潜在效用her-2-overexpressed乳腺癌的赫赛汀的体外和体内的比较研究.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 486568, 12 pages doi:10.1155/2012/486568 Research Article The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: An In Vitro and In Vivo Comparison Study with Herceptin Hung-Wen Lai,1, 2 Su-Yu Chien,3, 4, 5 Shou-Jen Kuo,1, 4, 5 Ling-Ming Tseng,6, 7 Hui-Yi Lin,8 Chin-Wen Chi,2 and Dar-Ren Chen1, 4 1 Comprehensive Breast Cancer Center, Changhua Christian Hospital, Changhua 50006, Taiwan 2 Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan 3 Department of Pharmacology, Changhua Christian Hospital, Changhua 50006, Taiwan 4 School of Medicine, College of Health Care and Management, Chung Shan Medical University, Taichung 40201, Taiwan 5 School of Nutrition, College of Health Care and Management, Chung Shan Medical University, Taichung 40201, Taiwan 6 Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan 7 School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan 8 Department of Pharmacology, School of Pharmacology, China Medical University, Taichung 40402, Taiwan Correspondence should be addressed to Dar-Ren Chen, darren chen@.tw Received 11 November 2010; Revised 21 March 2011; Accepted 2 May 2011 Academic Editor: Jae Youl Cho Copyright © 2012 Hung-Wen Lai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. HER-2 is an important oncoprotein overexpressed in about 15–25% of breast cancers. We hypothesized that the ability of curcumin