the prognostic impact of protein expression of e-cadherin-catenin complexes differs between rectal and colon carcinomae-cadherin-catenin复合物的蛋白质表达的预后影响直肠和结肠癌癌之间的不同.pdfVIP

Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2010, Article ID 616023, 7 pages doi:10.1155/2010/616023 Clinical Study The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma Rolf Aamodt,1, 2 Johan Bondi,2 Solveig Norheim Andersen,1, 3 Arne Bakka,1, 2 Geir Bukholm,4, 5 and Ida R. K. Bukholm1, 2, 6 1 Faculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, Norway 2 Department of Digestive Surgery, Akershus University Hospital, 1478 Loerenskog, Norway 3 Department of Pathology, Akershus University Hospital, 1478 Loerenskog, Norway 4 Institute of Health and Society, University of Oslo, Forskningsveien 3A, 0373 Oslo, Norway 5 Norwegian Unit for Patient Safety, Norwegian Knowledge Centre for the Health Services, Box 7004 St.Olavsplass, 0130 Oslo, Norway 6 Department of Health Promotion, Akershus University Hospital, 1478 Loerenskog, Norway Correspondence should be addressed to Rolf Aamodt, rolf.aamodt@medisin.uio.no Received 9 February 2010; Revised 15 June 2010; Accepted 6 July 2010 Academic Editor: Robert Odze Copyright © 2010 Rolf Aamodt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The E-cadherin-catenin complex provides cell-cell adhesion. In order for a carcinoma to metastasize, cancer cells must let go of their hold of neighboring cells in the primary tumor. The presence of components of the E-cadherin-catenin complex in 246 rectal adenocarcinomas was examined by immunohistochemistry and compared to their presence in 219 colon carcinomas. The expression data were