the current knowledge of the role of ppar in hepatic ischemia-reperfusion injury当前的知识ppar在肝缺血再灌注损伤的作用.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2012, Article ID 802384, 14 pages doi:10.1155/2012/802384 Review Article The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury ´ 1 ´ 1 2 M. Elias-Miro, M. B. Jimenez-Castro, M. Mendes-Braz, ´ 1 1, 3 A. Casillas-Ramırez, and C. Peralta 1 Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Esther Koplowitz Center, Rosello 149–153, ` ´ 3rd Floor, Offi ce 3.8, 08036 Barcelona, Spain 2 Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade de Sao Paulo, 14049-900 Sao Paulo, SP, Brazil 3 Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas, 08036 Barcelona, Spain ´ ´ ´ Correspondence should be addressed to C. Peralta, cperalta@clinic.ub.es Received 22 December 2011; Accepted 16 March 2012 Academic Editor: Stefan Alexson ´ Copyright © 2012 M. Elias-Miro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and