the protective effect of yi shen juan bi pill in arthritic rats with castration-induced kidney deficiency易建联沈胡安bi药丸的防护效果与castration-induced关节炎大鼠肾脏缺乏.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 102641, 8 pages doi:10.1155/2012/102641 Research Article The Protective Effect of Yi Shen Juan Bi Pill in Arthritic Rats with Castration-Induced Kidney Deficiency Hongyan Zhao,1 Jian Li,2 Xiaojuan He,3 Cheng Lu,3 Cheng Xiao,4 Xuyan Niu,3 Ning Zhao,3 Dahong Ju,3 and Aiping Lu3 1 Institute of Basic Theory of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China 2 Preclinical College, Beijing University of Chinese Medicine, Beijing 100029, China 3 Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing 100700, China 4 China-Japan Friendship Hospital, Beijing 100029, China Correspondence should be addressed to Aiping Lu, la126.com Received 25 September 2011; Revised 28 November 2011; Accepted 9 December 2011 Academic Editor: Wei Jia Copyright © 2012 Hongyan Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Androgens have been linked to the onset, severity, and progression of rheumatoid arthritis (RA). In traditional Chinese medicine (TCM), the most common pattern in RA is kidney deficiency, which partly corresponds to a low sex hormone state. In this study, TCM kidney deficiency was induced in male Sprague-Dawley rats with castration surgery, and a TCM preparation, Yi Shen Juan Bi Pill (YJB), was used to treat collagen induced arthritis (CIA) rats with castration. Metabolomic technique was used to evaluate the pharmacological mechanism in castrated CIA rats treated by YJB. The results showed that castration sign