the radiation response of sarcomas by histologic subtypes a review with special emphasis given to results achieved with razoxane辐射响应的肉瘤组织学亚型审查特别重视与razoxane成果.pdfVIP

Hindawi Publishing Corporation Sarcoma Volume 2006, Article ID 87367, Pages 1–9 DOI 10.1155/SRCM/2006/87367 Review Article The Radiation Response of Sarcomas by Histologic Subtypes: A Review With Special Emphasis Given to Results Achieved With Razoxane Walter Rhomberg Department of Radiooncology, General Hospital, Carinagasse 47, 6800 Feldkirch, Austria Received 25 June 2005; Revised 6 January 2006; Accepted 14 February 2006 Purpose. Relatively few results are available in the literature about the radiation response of unresectable sarcomas in relation to their histology. Therefore, an attempt was made to summarize the present situation. Materials and methods. This report is based on a review of the literature and the author’s own experience. Adult-type soft tissue sarcomas, chondrosarcomas, and chordomas were analyzed. Radioresponse was mainly associated with the degree of tumor shrinkage, that is, objective responses. Histopathologic responses, that is, the degree of necrosis, are only discussed in relation to radiation treatment reports of soft tissue sarcomas as a group. Results. Radiation therapy alone leads to major responses in about 50% of lipo-, fibro-, leiomyo-, or chondrosarcomas. The response rate is less than 50% in malignant fibrous histiocytomas, synovial, neurogenic, and other rare soft tissue sarcomas. The response rates may increase up to 75% through the addition of radiosensitizers such as halogenated pyrimidines or razoxane, or by the use of high-LET irradiation. Angiosarcomas become clearly more responsive if biologicals, angiomodulating, and/or tubulin affinic substances are given together with radiation therapy. Razoxane is able to increase the duration and quality of responses even in difficult-to-treat tumors like chondrosarcomas or chordomas. Conclusions. The available data dem