the redox imbalance and the reduction of contractile protein content in rat hearts administered with l-thyroxine and doxorubicin氧化还原平衡和减少老鼠的心脏收缩蛋白质含量的管理与甲状腺素和阿霉素.pdfVIP

Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2012, Article ID 681367, 9 pages doi:10.1155/2012/681367 Research Article The Redox Imbalance and the Reduction of Contractile Protein Content in Rat Hearts Administered with L-Thyroxine and Doxorubicin Agnieszka Korga,1 Jaroslaw Dudka,1 Franciszek Burdan,2 Justyna Sliwinska,3 Slawomir Mandziuk,4 and Katarzyna Dawidek-Pietryka5 1 Medical Biology Unit, Medical University of Lublin, 20-950 Lublin, Poland 2 Human Anatomy Department, Medical University of Lublin, 20-950 Lublin, Poland 3 Clinical Pathomorphology Department, Medical University of Lublin, 20-950 Lublin, Poland 4 Oncological Pneumology and Alergology Department, Medical University of Lublin, 20-950 Lublin, Poland 5 Lloyds Pharmacy, 333 Meadowhead, Sheffi eld S8 9TU, UK Correspondence should be addressed to Agnieszka Korga, a.korg@interia.pl Received 7 August 2011; Revised 15 October 2011; Accepted 15 November 2011 Academic Editor: Neelam Khaper Copyright © 2012 Agnieszka Korga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Oxidative stress and disorders in calcium balance play a crucial role in the doxorubicin-induced cardiotoxicity. Moreover, many cardiotoxic targets of doxorubicin are regulated by iodothyronine hormones. The aim of the study was to evaluate effects of tetraiodothyronine (0.2, 2 mg/L) on oxidative stress in the cardiac muscle as well as contractility and cardiomyocyte damage markers in rats receiving doxorubicin (1.5 mg/kg) once a week for ten weeks. Doxorubicin was administered alone (DOX) or