the relation between fructose-induced metabolic syndrome and altered renal haemodynamic and excretory function in the ratfructose-induced代谢综合征之间的关系和大鼠肾脏血液动力学的改变和排泄功能.pdfVIP

SAGE-Hindawi Access to Research International Journal of Nephrology Volume 2011, Article ID 934659, 17 pages doi:10.4061/2011/934659 Review Article The Relation between Fructose-Induced Metabolic Syndrome and Altered Renal Haemodynamic and Excretory Function in the Rat Mohammed H. Abdulla,1 Munavvar A. Sattar,1 and Edward J. Johns2 1 School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia 2 Department of Physiology, Western gateway Building, University College Cork, College Road, Cork, Ireland Correspondence should be addressed to Mohammed H. Abdulla, mdapharm78@yahoo.co.uk and Edward J. Johns, e.j.johns@ucc.ie Received 18 February 2011; Revised 30 April 2011; Accepted 15 May 2011 Academic Editor: Frank Park Copyright © 2011 Mohammed H. Abdulla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This paper explores the possible relationships between dietary fructose and altered neurohumoral regulation of renal haemodynamic and excretory function in this model of metabolic syndrome. Fructose consumption induces hyperinsulinemia, hypertriglyceridaemia, insulin resistance, and hypertension. The pathogenesis of fructose-induced hypertension is dubious and involves numerous pathways acting both singly and together. In addition, hyperinsulinemia and hypertension contribute significantly to progressive renal disease in fructose-fed rats. Moreover, increased activity of the renin-angiotensin and sympathetic nervous systems leading to downregulation of receptors may be responsible for the blunted vascular sensitivity to an