the reorientation of t-cell polarity and inhibition of immunological synapse formation by cd46 involves its recruitment to lipid raftst细胞极性的重新定位和抑制免疫突触形成的cd46涉及脂质筏的招聘.pdfVIP

Hindawi Publishing Corporation Journal of Lipids Volume 2011, Article ID 521863, 10 pages doi:10.1155/2011/521863 Research Article The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts Mandy J. Ludford-Menting,1 Blessing Crimeen-Irwin,1 Jane Oliaro,1, 2 Anupama Pasam,1, 2 David Williamson,3, 4 Natalie Pedersen,1 Patricia Guillaumot,5 Dale Christansen,6 Serge Manie,5 Katharina Gaus,3, 4 and Sarah M. Russell1, 2, 7 1 Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia 2 Department of Surgery, University of Melbourne, Parkville, VIC 3010, Australia 3 Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia 4 Department of Haematology, The Prince of Wales Hospital, Sydney, NSW 2052, Australia 5 Laboratoire de G´en´etique, Signalisation et Cancer. CNRS, UMR 5201, Universit´e Claude Bernard Lyon 1, Lyon, France 6 Department of Pathology, University of Melbourne, Parkville, VIC 3010, Australia 7 Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, VIC 3122, Australia Correspondence should be addressed to Katharina Gaus, k.gaus@.au and Sarah M. Russell, sarah.russell@ Received 27 August 2010; Accepted 1 December 2010 Academic Editor: Teodor Brumeanu Copyright © 2011 Mandy J. Ludford-Menting et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Many infectious agents utilize CD46 for infection of human cells, and therapeutic applications of CD46-binding viruses are now being explored. Besides mediating internalization to ena