topical apigenin alleviates cutaneous inflammation in murine models在小鼠模型中局部芹黄素减轻皮肤炎症.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 912028, 7 pages doi:10.1155/2012/912028 Research Article Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models Mao-Qiang Man,1, 2 Melanie Hupe,2 Richard Sun,2 George Man,2 Theodora M. Mauro,2 and Peter M. Elias2 1 The Center for Skin Physiology Research, Dalian Skin Disease Hospital, Liaoning 116021, China 2 Dermatology Service, Veterans Aff airs Medical Center and Department of Dermatology, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA Correspondence should be addressed to Mao-Qiang Man, mqman@ Received 24 July 2012; Revised 10 October 2012; Accepted 18 October 2012 Academic Editor: Wagner Vilegas Copyright © 2012 Mao-Qiang Man et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Herbal medicines have been used in preventing and treating skin disorders for centuries. It has been demonstrated that systemic administration of chrysanthemum extract exhibits anti-inflammatory properties. However, whether topical applications of apigenin, a constituent of chrysanthemum extract, influence cutaneous inflammation is still unclear. In the present study, we first tested whether topical applications of apigenin alleviate cutaneous inflammation in murine models of acute dermatitis. The murine models of acute allergic contact dermatitis and acute irritant contact dermatitis were established by topical application of oxazolone and phorbol 12-myristate 13-acetate (TPA), respectively. Inflammation was assessed in both dermati