生物药剂学与药物动力学（Biopharmaceutics and Pharmacokinetics）.docVIP

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生物药剂学与药物动力学（Biopharmaceutics and Pharmacokinetics）.doc

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生物药剂学与药物动力学（Biopharmaceutics and Pharmacokinetics）

生物药剂学与药物动力学（Biopharmaceutics and Pharmacokinetics） 17. hepatic circulation: the phenomenon that a drug excreted in bile or whose metabolite moves back through the small intestine and is absorbed back into the hepatic portal vein. 6. level 1 velocity process: the rate at which a drug is transported in a part of the body is proportional to the amount of the drug or the concentration of the blood. 7. clearance rate: the volume of drug plasma volume or unit time removed from the body per unit time, the apparent volume of the drug removed from the body. 9. apparent volume of distribution: the ratio constant between the concentration of drugs in whole blood or plasma and the amount of drug in the body. It is an important parameter of pharmacokinetics. 8. two compartment model: when the drug enters the body, it can quickly enter certain parts of the body, but it takes some time for other parts to complete the distribution. The quick shift view divides the organism into two separate systems with different levels of drug distribution, the two compartment model. 7. single compartment model: the drug enters the body and is rapidly distributed throughout the tissues, organs, and body fluids and then eliminated by excretion or structural transformation. At this point, the organism can be regarded as a homogeneous unit of the dynamic equilibrium of drug transport, a compartment which is called a single compartment model. Transmembrane transport of drugs (a) passive transport: refers to the drug only by the side to the side of the high concentration of low concentration of transport, drug concentration and membrane transport speed on both sides of the difference (concentration gradient), and the concentration gradient is proportional to the concentration gradient is more likely to spread. Passive transport involves dissolved diffusion, limited diffusion and facilitated diffusion. 3. solubility diffusion: simple diffusion, also known as lipid soluble diffusion, refers to the diffus