白癜风百科（Vitiligo Encyclopedia）.doc

白癜风百科（Vitiligo Encyclopedia） Vitiligo Encyclopedia Vitiligo etiology The cause of the disease is not clear yet. Recent studies suggest that it is related to the following factors: 1. genetics that vitiligo is an autosomal dominant skin disease, foreign authors statistics 30% patients have a positive family history, found that monozygotic twins two incidence, reported a positive family history was 3% ~ 12%, compared with the previous reports. The relationship between the 2. theory of autoimmunity autoimmune theory and the incidence of vitiligo is getting more attention, many scholars pay attention to the patients and their family members with higher rates of autoimmune diseases, common thyroiditis, hyperthyroidism or hypothyroidism, diabetes, chronic adrenal insufficiency, pernicious anemia, rheumatoid arthritis, malignant melanoma, and serum of patients with vitiligo, with specific antibodies were detected in various organs, such as anti thyroid antibodies, anti gastric parietal cell antibody, anti adrenal antibodies, anti parathyroid antibody, anti smooth muscle antibody, and the detection rate is higher, also suffering from autoimmune diseases, vitiligo incidence is higher than the general population to 10 15 times, recently also found that vitiligo patients have anti melanocyte surface antigens, called vitiligo antibodies, the drop Of patients with skin depigmentation degree and titer with lesions of the area to expand, also found suffering from vitiligo animal has a similar phenomenon, the disease is the melanocyte autoimmune diseases, Behl (1977) were found in the white spot edge mononuclear cell aggregation, invasion of the dermal epidermal junction, by the basement membrane damage into epidermis, melanocytes and melanin the absence, that this disease may be delayed hypersensitivity of autoimmune disease. In addition, oral or topical corticosteroids, especially the curative effect according to lesion dermatomal distribution is better, but also indirect evidenc