糖皮质激素药理作用（Pharmacological effects of glucocorticoids）.docVIP

糖皮质激素药理作用（Pharmacological effects of glucocorticoids） Pharmacological effects of glucocorticoids Anti-inflammatory glucocorticoids have strong anti-inflammatory effects, can cause the inflammation against various reasons: physical damage, such as burns, trauma and so on; the chemical injury, such as acid, alkali injury, and biological injury, such as bacteria, virus infection, the immune injury, such as various types of allergic reactions, 5. Aseptic inflammation, such as ischemic tissue injury. In the early stage of acute inflammation of glucocorticoids can reduce early inflammatory exudation and edema, capillary dilatation, leukocyte infiltration and phagocytic reaction, so as to improve the clinical symptoms of red, swelling, heat, pain and other early inflammatory; inflammation in the late application of glucocorticoids can inhibit ingrowth of capillaries and fibroblasts the proliferation, synthesis and proliferation of granulation tissue, inhibiting collagen mucopolysaccharide, thereby preventing the inflammatory adhesion and scar formation, reduce inflammatory sequelae. It must be noted, inflammation is a defense function of the body, an important inflammatory response is late tissue repair, so glucocorticoid in inhibiting inflammation and alleviate the symptoms at the same time, but also reduces the bodys defense and repair function, can lead to the spread of infection and delayed wound healing. Immunosuppressive and anti allergic glucocorticoid has inhibitory effect on several aspects of the immune response, can relieve the many symptoms of allergic diseases and pathological changes caused by inhibition due to allergic reactions, such as allergic hyperemia, edema, exudation, rash, muscle spasm and cell damage, inhibit organ transplant rejection for autoimmune diseases, can also play a certain effect in the near future. The glucocorticoid and immunosuppressive effects of the following factors: inhibition of phagocytic cell antigen and inhibition of lymphocyte