老年人用药原则（Medication principles for the elderly）.docVIP

老年人用药原则（Medication principles for the elderly） Third lessons Medication principles for the elderly Pharmacokinetics of drugs in the elderly Concept: referred to as geriatric pharmacokinetics, describes drugs used in older adults The action (absorption, distribution, metabolism, and excretion) of blood drugs Time, process and characteristics of concentration rise and fall. We all learn in pharmacokinetic process there are age-related changes, can be directly Influence on serum concentration in the elderly. Characteristics of pharmacokinetics of senile drugs - absorption Absorption (absorption) - refers to the penetration of a drug from the site of the drug into the blood vessel The process of entering the circulation of the blood. Conclusion: the gastrointestinal mucosa in elderly people is gradually shrinking, peristalsis is slowing and blood supply is decreasing Less and gastric acid deficiency, but the absorption of drugs (passive operation absorption of drugs) Less affected Glucose, vitamin B1, calcium, and iron: ?? Absorption of drugs for active transport, relax, absorption decreases with age ?? The main reason: with the absorption of the drug required carrier and enzyme activity related to: Characteristics of pharmacokinetics of senile drugs - absorption Weakly acidic drugs: Why?: ?? Here, gastric stomach acid weak acid dissociation increases, gastric absorption rate decreases, But the decrease in gastric emptying, drug retention time relative increase drug absorption time increase ?? - small intestine peristalsis down, relax, counteract the intestinal absorption of drug supply And the decrease of absorbed area caused by the decrease of absorbed area The majority of drugs (drug absorption in the passive operation) on the elderly and absorption There was no significant difference between adults Distribution characteristics of pharmacokinetics in elderly patients Distribution (distribution) - refers to the continuous passage of a drug through the bloodstream The