肿瘤小分子靶向药物分类（Small molecule tumor targeting drug classification）.docVIP

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肿瘤小分子靶向药物分类（Small molecule tumor targeting drug classification）.doc

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肿瘤小分子靶向药物分类（Small molecule tumor targeting drug classification）

肿瘤小分子靶向药物分类（Small molecule tumor targeting drug classification） Small molecule tumor targeting drug classification Nowadays, the treatment methods of cancer are diversified. Among them, targeted therapy is a new method of treatment. Because of the small side effects and prominent curative effect, the cost of targeted therapy is relatively high. Molecular targeted drugs are drugs in molecular biology and molecular genetics on the basis of the theory, to the therapeutic effect because of its precise target, compared with the traditional chemotherapy drugs have many advantages, the formation of a new field of cancer therapy, provides a method for small adverse reaction for cancer treatment. In the past 20 years, with the development of medical science, a large number of tumor cells the expression level for new anticancer drug targets have been developed, and gradually become a clinical, including signal transduction inhibitors, angiogenesis inhibitors, targeting telomerase inhibitors and tumor drug resistance reversal agent of needle. Attack the tumor target in many aspects, the present research is mature mainly target tumor cells (antigen or antibody), such as cell differentiation associated antigens (CD13, CD20, CD22, CD33, CD52, CD117), cell signaling molecules such as epidermal growth factor (EGF) and its receptor (EGFR) and vascular endothelial growth factor (VEGF) and its receptor tyrosine kinase, and farnesyl transferase, matrix metalloproteinase. There is no uniform classification method for molecular target drugs. According to the different targets, they can be divided into the following 4 categories. Protein kinase The cell differentiation signal transduction factor contains a large number of protein kinase families. In the process of cell signal transduction, protein tyrosine kinase is very important, it can be based on phosphoric acid catalyzed ATP transfer to many important protein tyrosine residues on the phosphorylation resulted in activation of conducti