大剂量甲基强松龙冲击疗法治疗急性视神经炎有效性的系统评价.pdfVIP

摘 要 大剂量甲基强的松龙冲击疗法治疗急性视神经炎 有效性的系统评价 研究生：王璐 导师：陈雪艺 教授 摘 要 目的：系统评价大剂量甲基强的松龙冲击疗法与安慰剂治疗急性视神经炎的临 床疗效和安全性。方法：检索Medline 、OVID 和中文科技期刊全文数据库、维普中 文科技期刊数据库，检索时间截至2009 年5 月。按照文内所述纳入标准收集大剂量 静脉应用激素冲击治疗急性视神经炎的相关研究文献，采用Meta 分析对检索文献进 行综合定量评价。结果：IVMP 与安慰剂比较共纳入3 个研究433 例患者，IVMP 在 早期显示出相对优于安慰剂组的有效率，但在六个月后，两组有效率的差异无统计 学意义。结论：早期静脉注射大剂量甲基强的松龙可加快急性视神经炎的康复，六 个月后与安慰剂组无明显差别。在降低急性视神经炎的复发率、甲基强的松龙的最 佳用药剂量及疗程仍需开展更多设计良好、方法学质量更高的随机对照试验来证实。 关键词：视神经炎；甲基强的松龙；安慰剂；随机；对照； —1— 新疆医科大学医学硕士学位论文 High dosage intravenous methyprednisolone in the treatment of acute optic neuritis ：a Meta-Analysis of randomized controlled clinical trials Postgraduate ：Wang Lu Supervisor ：Chen Xue Yi professor Abstract Objective ：To investigate efficiency and security in the treatment of acute optic neuritis ，we conducted a meta-analysis of randomized controlled clinical trials on methyprednisolone and placebo for acute optic neuritis. Methods ：The literature search, study selection and assessment, data collection and analysis were undertaken by two reviewers according to the Cochrane Handbook for Systematic Reviews of Interventions. Of the 3 trials comparing methyprednisolone and placebo were selected for this review. Result ：Three studies involving 433 patients were included. The IVMP regiment was superior to the placebo regiment at early times. But the groups were no significant difference at six months. Conclusion ：IVMP is therefore effective in accelerating short-term recovery in patients with acute optic neuritis. Whether IVMP are also effective in reducing the risk of relapse, and the optimal