宫颈癌和宫颈上皮内瘤变相关危险因素分析.pdfVIP

摘 要 宫颈癌及宫颈上皮内瘤变相关危险因素分析 研究生：董 岩 导师：程静新 副教授 摘 要 目的：探讨宫颈癌和宫颈上皮内瘤变发生的相关危险因素。方法：采用流行病 学问卷调查、妇科检查和实验室检查的方法，对我院门诊和住院的 274 例患者（其 中宫颈癌80 例、宫颈上皮内瘤变114 例、正常宫颈80 例）进行临床流行病学调查、 妇科检查和HC2-HPV-DNA 检测，对各相关因素进行非条件logistic 回归分析。结果： ⑴宫颈上皮内瘤变发生的独立危险因素为生产次数多、初次性行为年龄小和宫颈高 危型HPV 病毒感染，而同房后经常阴道冲洗在宫颈上皮内瘤变的发生中起保护作用。 ⑵宫颈癌发生的独立危险因素为生产次数多、有多个性伴侣、初次性行为年龄小、 口服避孕药、宫颈糜烂和宫颈高危型HPV 病毒感染，而受教育程度高、经常进行健 康体检在宫颈癌的发生中起保护作用。结论:通过研究发现宫颈癌和宫颈上皮内瘤 变既有共同的危险因素，又有各自不同的危险因素。分析各危险因素在宫颈癌和宫 颈上皮内瘤变发病中的作用，为宫颈癌及宫颈上皮内瘤变合理筛查提供客观依据。 关键词：宫颈癌；宫颈上皮内瘤变；危险因素；人乳头瘤病毒 — 1— 新疆医科大学医学硕士学位论文 Study of the Association risk factors of cervical cancer and cervical intraepithelial neoplasia Postgraduate: Dong Yan Supervisor: Cheng Jingxin Abstract Objective :To abrobe the risk factors of cervical cancer and cervical intraepithelial neoplasia about cervical lesion patients. Methods:Through the form of clinical epidemiological questionnaire, Gynecologic and laboratory examination for 274 cases of patients, there were 114 cases of patients with CIN, 80 cases of patients with cervical cancer, 80 cases of patients with non-cervical cancer. Results: ⑴CIN had significantly risk factor with multiple accouchement, have sexual behavior at young age, high-risk human papaillpmvirus infection, and protected factor with bathe vagina regularity. ⑵Cervical cancer had significantly risk factor with multiple accouchement, have sexual behavior at young age, more than two sex partners, oral contraceptives, high-risk human papaillpmvirus infection, and protected factor with high-education level, health exami