about the impact of of catgut embedding of clozapine rat hypothalamic monoamine neurotransmitters（的影响肠线嵌入氯氮平的大鼠下丘脑单胺神经递质）.docVIP

About the impact of of catgut embedding of clozapine rat hypothalamic monoamine neurotransmitters [Abstract] observed the of catgut embedding of clozapine rat hypothalamic monoamine neurotransmitters [Methods] 36 SD rats were randomly divided into the catgut embedding group clozapine group, and blank control group. blank control group, the other two groups of rats were orally Clozapine 5mg ?kg-1 ?d-1 increasing to 30mg ?kg-1 ?d-1, and then down to 22mg ?kg-1 ?d -1 and maintained until the end of the experiment. clozapine 60d catgut embedding group select two sets of acupuncture points: ① Baihui, Xinyu (double, Qu Chi (double, ② Ojo, Pishu, (double, Zusanli (double) the alternate embedding, treatment 5d, a total of 12 times. observed changes in body weight of rats before and after treatment, and detection of hypothalamic monoamine neurotransmitters dopamine (DA and 5-hydroxytryptamine (5 HT content. [results ] long-term use of clozapine body weight in rats can be increased significantly, DA and 5 HT content was significantly lower (all P lt;0.05 or P lt;0.01, catgut embedding therapy can significantly suppress the increase in body weight of rats elevated hypothalamic DA and 5 HT content (P lt;0.05 [Conclusion] The catgut embedding mechanism to mitigate clozapine side effects may be associated with increased under the hypothalamic monoamine neurotransmitter content. [Keywords] catgut embedding / therapeutic applications of mental disorders / acupoint therapy monoamine neurotransmitter disease model animals rat Clozapine (clozapine) atypical antipsychotics, and its low price, the curative effect is a commonly used drug for the treatment of refractory psychiatric disease clinical easily lead to obesity, blood glucose and lipid abnormalities range of side effects, but long-term use It has been reported that [1] The mechanism may be related to the neurotransmitter and neuroendocrine antipsychotics by anti-adrenergic blocking dopamine (DA receptor and antag