activity differences between different vessel segments puerarin mechanism of vasodilation（活动之间的差异不同的血管舒张血管段葛根素机制）.docVIP

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activity differences between different vessel segments puerarin mechanism of vasodilation（活动之间的差异不同的血管舒张血管段葛根素机制）.doc

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activity differences between different vessel segments puerarin mechanism of vasodilation（活动之间的差异不同的血管舒张血管段葛根素机制）

Activity differences between different vessel segments puerarin Mechanism of vasodilation Abstract: In vitro vascular ring trial activity differences between different vessel segments puerarin (Puerarin, Pue difference in diastolic function and its mechanism. Methods: SD rats 36, prepared by conventional methods in vitro vascular ring specimens, divided into endothelial Full group and endothelium two groups, each of which has a distal, middle and proximal segments three groups with isolated perfused rat aortic vascular rings, vascular basal tension set at 9.8 ?10-3 N (1 g), measured vascular ring tone and each group puerarin pEC50. endothelium-intact groups were added L-NAME and puerarin (bath final concentration of 10-4 mol #8226; L-1 co-incubation of serum vascular ring tone changes, and calculated pEC50. Results: puerarin 10-7 ~ 10-4 mol #8226; L-1 within the scope of the abdominal aorta in a dose-dependent vasodilatory effect, 10-4 mol #8226; L-1 reached (61.2 + -3.7 % of the maximum relaxation, endothelium after its vasodilator effect can be reduced (34.6 + -6.1%, the difference was statistically significant (P lt;0.05, distal segment intact endothelium endothelium and Emax are closer to the heart ring and middle the difference was statistically significant (P lt;0.01, endothelium-intact distal segment group, puerarin with L-arginine (L-NAME co-incubation, Emax decreased significantly (P lt;0.05, while the proximal segment and the middle group, L-NAME were incubated with puerarin group vasodilation by inhibition compared with puerarin group showed no significant difference (Pgt; 0.05. pEC50 each group the difference was not statistically significant (Pgt; 0.05. Conclusions : puerarin endothelium-dependent vasodilator effect, but a different vessel segments there are differences in diastolic activity, this effect is related with the NO system. Keywords: puerarin, thoracic aortic rings, NO synthase, vasodilation Puerarin (Puerarin, Pue has vasodilator,