advanced oxidation protein products of research（先进的氧化蛋白质产品的研究）.docVIP

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advanced oxidation protein products of research（先进的氧化蛋白质产品的研究）.doc

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advanced oxidation protein products of research（先进的氧化蛋白质产品的研究）

Advanced oxidation protein products of research Abstract: The advanced oxidation protein products (AOPPs) is a newly discovered class of uremic toxins can stimulate monocyte respiratory burst, stimulate the tumor necrosis factor (TNF-@-based synthesis of pro-inflammatory cytokines, release, monocytes trigger inflammation, caused by systemic microinflammation. chronic renal failure (CRF patients with immune dysfunction, atherosclerosis, dialysis-related amyloidosis and other long-term complications of important pathogenic link. this paper, recent About AOPPs views are reviewed. Keywords: advanced oxidation protein products, research, progress 1 AOPPs sources and characteristics AOPPs is Witko-Sarsat equal to 1996 in patients with chronic renal failure (CRF) found in the plasma of patients, whose main ingredient is serum albumin by free radicals and reactive oxygen system after oxidation product of CRF and hemodialysis (HD) patients with immune dysfunction, atherosclerotic cardiovascular disease, dialysis-related amyloidosis important pathogenic aspects of long-term complications, is the result of chloride oxidation reaction in the oxidative stress from phagocytic cell activation sub-generated oxygen acid or chloramine oxidation of serum albumin generated dual tyrosine protein containing material cross-linked by two tyrosine residues to form the covalent double tyrosine , a specific marker for protein oxidation by one into a high molecular weight and low molecular weight AOPPs AOPPs. molecular weight AOPPs, a molecular weight of 670 kDa, albumin polymer, mostly found in the albumin, in acidic conditions Next, at 340 nm absorption peak is specific, the molecular structure contains a large number of two-tyrosine, and a carbonyl group, with the damage of oxygen free radicals, oxidative stress response. study, AOPPs structural and biological activity with the advanced glycosylation end products (AGE) similar. AGE occurring protein amino-terminal non-enzymatic gly