神经节苷脂GM-%2c3-对人单核样白血病J6-2细胞磷脂酶C-%2cγ-1转位和生长因子受体磷酸化地影响.pdf

Effects of the on translocationof Ganglioside GM3 Phospholipase andthe ofGrowth 研l Factor in phosphorylation Receptor Human LeukemiaJ6．2eell Line MS Candidate：Bi Xiaoyu Keli Supervisor：Ma Specialty：Biochemistry andMolecular Biology Abstract has tobea cell GM3 been Ganglioside proved physiological in humanleukemiacell differentiationinducerseveral lines．However,the differentiationmechanismof remainsunclear．Our inducing GM3 previous human workshown Caninduce leukemiaJ6·-2 has that GM3 monocytold celllinetodifferentiatethe routeand along monocyte／macrophage J6·2 inhibitcell C(PLC)of simultaneously phospholipase phosphatidyl less ofPI-PLCcanresultinthe activity inositol(PI)specificity．nle the ofPKCa from decreaseof inhibits it DAG；which activity byinhibiting themechanismstill the tothe membr