探讨甲羟孕酮治疗对更年期大鼠脾细胞凋亡与Th1%2fTh2平衡地影响.pdfVIP

of treatmenton Effects splenocyte Medroxyprogesterone in rats and balance Thl／Thz menopausal apoptosis 【Abstrctl Background： immunefunctionis sexhormonesand The between very relationship thathormone complicated．Thissuggests replacementtherapy(HRT)in womenhave effectsonimmunefunction． may pleiotropic post．menopausal few were abouttheeffectsof immune But studiesreported progesterone(P)on function． Object： howthe of We the toobserve supplement designstudy andThl／Th2banlanceinvivo． acetate(MPA)affectslymphocyteapoptosis Metbods： 1、WeusedfemaleSDrats．Threewere 0，2．5 groupsset：younggroup(n。1 lml／ddistilled O，12 months group(n。1 ol∞，taking water；menopausal months lml／ddistilled acetate(MPA) old)，takmg water；medroxyprogesterone treated months MPA The and 2mg／kg／ddrug group(n=10，12old)，taking waterwere 0nthefirst orally day． given 3 weresacrificedcarotid 2、Aftermonths，rats by arteryexanginination，the