a novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis一个新颖的方法来衡量的贡献整体净蛋白水解活性基质金属蛋白酶在滑膜液的关节炎患者.pdfVIP

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a novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis一个新颖的方法来衡量的贡献整体净蛋白水解活性基质金属蛋白酶在滑膜液的关节炎患者.pdf

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a novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis一个新颖的方法来衡量的贡献整体净蛋白水解活性基质金属蛋白酶在滑膜液的关节炎患者

Available online /content/8/4/R125 Vol 8 No 4 Open Access Research article A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis 1 2 2 1 Nathalie Simard , Gilles Boire , Artur J de Brum-Fernandes and Yves St-Pierre 1INRS-Institut Armand-Frappier, University of Québec, Laval, Québec, Canada 2Division of Rheumatology, Department of Medicine, Centre hospitalier universitaire de Sherbrooke, Université de Sherbrooke, Québec, Canada Corresponding author: Yves St-Pierre, yves.st-pierre@iaf.inrs.ca Received: 13 Apr 2006 Revisions requested: 24 May 2006 Revisions received: 13 Jun 2006 Accepted: 14 Jul 2006 Published: 19 Jul 2006 Arthritis Research Therapy 2006, 8:R125 (doi:10.1186/ar2014) This article is online at: /content/8/4/R125 © 2006 Simard et al., licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Despite decades of research, only a very limited number of overall activity in inflammatory arthritis patients correlated matrix metalloproteinase (MMP) inhibitors have been successful positively with the number of infiltrated leukocytes and the serum in clinical trials of arthritis. One of the central problems level of C-reactive protein. No such correlations were found in associated with this fa