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a polymorphism in the dysbindin gene (dtnbp1) associated with multiple psychiatric disorders including schizophrenia小的多态性基因(dtnbp1)与多种精神疾病包括精神分裂症
Voisey et al. Behavioral and Brain Functions 2010, 6:41
/content/6/1/41
R E S E A R C H Open Access
Research
A polymorphism in the dysbindin gene (DTNBP1)
associated with multiple psychiatric disorders
including schizophrenia
1 1 1 2 1,3 1
Joanne Voisey , Christopher D Swagell , Ian P Hughes , Jason P Connor , Bruce R Lawford , Ross M Young and C
Phillip Morris*1
Abstract
Background: A number of studies have found associations between dysbindin (DTNBP1) polymorphisms and
schizophrenia. Recently we identified a DTNBP1 SNP (rs9370822) that is strongly associated with schizophrenia.
Individuals diagnosed with schizophrenia were nearly three times as likely to carry the CC genotype compared to the
AA genotype.
Methods: To investigate the importance of this SNP in the function of DTNBP1, a number of psychiatric conditions
including addictive behaviours and anxiety disorders were analysed for association with rs9370822.
Results: The DTNBP1 polymorphism was significantly associated with post-traumatic stress disorder (PTSD) as well as
nicotine and opiate dependence but not alcohol dependence. Individuals suffering PTSD were more than three times
as likely to carry the CC genotype compared to the AA genotype. Individuals with nicotine or opiate dependence were
more than twice as likely to carry the CC genotype compared to the AA genotype.
Conclusions: This study provides further support for the importance of DTNBP1 in psychiatric conditions and suggests
that there is a common underlying molecular defect involving DTNBP1 that contributes to the development of several
anxiety and addictive disorders that are generally recognised as separate clinical conditions. These disorde
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