原创力文档a profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis疱疹病毒的免疫反应的是与射线在风湿性关节炎关节损伤.pdfVIP
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a profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis疱疹病毒的免疫反应的是与射线在风湿性关节炎关节损伤
Davis et al. Arthritis Research Therapy 2012, 14:R24
/content/14/1/R24
RESEARCH ARTICLE Open Access
A profile of immune response to herpesvirus is
associated with radiographic joint damage in
rheumatoid arthritis
1* 2 3 4 5
John M Davis III , Keith L Knutson , John A Skinner , Michael A Strausbauch , Cynthia S Crowson ,
5 4 1,6 1,6
Terry M Therneau , Peter J Wettstein , Eric L Matteson and Sherine E Gabriel
Abstract
Introduction: Progression of joint damage despite appropriate therapy remains a significant problem for patients
with rheumatoid arthritis (RA). This study was undertaken to identify profiles of immune response that correlate
with radiographic joint damage as a first step toward the discovery of new pathogenic mechanisms of joint
destruction in RA.
Methods: The study included 58 patients with RA and 15 healthy controls. The profiles of cytokine release from
peripheral blood mononuclear cells (PBMC) in response to stimulation for 48 hours with one of six stimuli, or in
media alone, were measured. Immune response profiles identified for each stimulus were correlated with
radiographic joint damage as defined by the Sharp-van der Heijde score (SHS), before and after multivariable
adjustment. For profiles correlated with the SHS, the distributions of individual cytokines were evaluated in patients
according to the severity of joint damage and compared to healthy controls.
Results: The immune response profile for cytomegalovirus (CMV)/Epstein-Barr virus (EBV) stimulation was correlated
with both the SHS total and erosion scores (r = 0.31, P = 0.018 and r = 0.33, P = 0.011, respect
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