a review of gene delivery and stem cell based therapies for regenerating inner ear hair cells回顾基因传递和干细胞治疗内耳毛细胞的再生.pdfVIP

J. Funct. Biomater. 2011, 2, 249-270; doi:10.3390/jfb2030249 OPEN ACCESS Journal of Functional Biomaterials ISSN 2079-4983 /journal/jfb/ Article A Review of Gene Delivery and Stem Cell Based Therapies for Regenerating Inner Ear Hair Cells Keerthana Devarajan 1, Hinrich Staecker 2 and Michael S. Detamore 1,3,* 1 Bioengineering Program, University of Kansas, Lawrence, KS 66045, USA; E-Mail: keerthanad@ 2 Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS 66160, USA; E-Mail: hstaecker@ 3 Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS 66045, USA * Author to whom correspondence should be addressed; E-Mail: detamore@; Tel.: +1-785-864-4943; Fax: +1-785-864-4967. Received: 10 August 2011; in revised form: 31 August 2011 / Accepted: 5 September 2011 / Published: 13 September 2011 Abstract: Sensory neural hearing loss and vestibular dysfunction have become the most common forms of sensory defects, affecting millions of people worldwide. Developing effective therapies to restore hearing loss is challenging, owing to the limited regenerative capacity of the inner ear hair cells. With recent advances in understanding the developmental biology of mammalian and non-mammalian hair cells a variety of strateg