a pilot prospective study on closed loop controlled ventilation and oxygenation in ventilated children during the weaning phase飞行员前瞻性研究闭环控制通风和氧化在通风的孩子断奶阶段.pdfVIP

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a pilot prospective study on closed loop controlled ventilation and oxygenation in ventilated children during the weaning phase飞行员前瞻性研究闭环控制通风和氧化在通风的孩子断奶阶段.pdf

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a pilot prospective study on closed loop controlled ventilation and oxygenation in ventilated children during the weaning phase飞行员前瞻性研究闭环控制通风和氧化在通风的孩子断奶阶段

Jouvet et al. Critical Care 2012, 16:R85 /content/16/3/R85 RESEARCH Open Access A pilot prospective study on closed loop controlled ventilation and oxygenation in ventilated children during the weaning phase 1,2* 1 1 1 1,2 Philippe Jouvet , Allen Eddington , Valérie Payen , Alice Bordessoule , Guillaume Emeriaud , Ricardo Lopez Gasco3 and Marc Wysocki2 Abstract Introduction: The present study is a pilot prospective safety evaluation of a new closed loop computerised protocol on ventilation and oxygenation in stable, spontaneously breathing children weighing more than 7 kg, during the weaning phase of mechanical ventilation. Methods: Mechanically ventilated children ready to start the weaning process were ventilated for five periods of 60 minutes in the following order: pressure support ventilation, adaptive support ventilation (ASV), ASV plus a ventilation controller (ASV-CO ), ASV-CO plus an oxygenation controller (ASV-CO -O ) and pressure support 2 2 2 2 ventilation again. Based on breath-by-breath analysis, the percentage of time with normal ventilation as defined by a respiratory rate between 10 and 40 breaths/minute, tidal volume 5 ml/kg predicted body weight and end-tidal CO2 between 25 and 55 mmHg was determined. The number of manipulations and changes on the ventilator were also recorded. Results: Fifteen children, median aged 45 months, were investigated. No adverse event and no premature protocol termination were reported. ASV-CO and ASV-CO -O kept the patients within normal ventilation for,