a new friedelane type triterpene from euonymus hederaceus一个新的木栓烷型三萜烯从卫矛hederaceus.pdfVIP

Molecules 2009, 14, 2650-2655; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A New Friedelane Type Triterpene from Euonymus hederaceus Cui-Rong Sun 1,*, He-Jiao Hu 1, Run-Sheng Xu 1, Jie-Hong Yang 2 and Hai-Tong Wan 2,* 1 Department of Chemistry, Zhejiang University, Hangzhou 310027, China 2 Institute of Cardio-Cerbrovascular Disease, Zhejiang Chinese Medical University, Hangzhou 310053, China; E-mail: yangjiehong@ (J-H.Y.) * Authors to whom correspondence should be addressed; E-mails: suncuirong@ (C-R.S.), wanhaitong@ (H-T.W.) Received: 22 June 2009; in revised form: 10 July 2009 / Accepted: 15 July 2009 / Published: 17 July 2009 Abstract: Euonymus hederaceus is distributed widely in the south of China; its stems and leaves have been used as folk medicines to treat many diseases such as renal deficiency and chronic diarrhea, traumatic injury, and abnormal menstruation. Chemical investigation of the leaves and stems of Euonymus hederaceus resulted in the isolation for the first time and characterization of a new friedelane type triterpene with a molecular mass of 472 and molecular formula of C30H48O4 by high resolution mass spectrometry. The 1H-NMR 13C-NMR and DEPT1350 spectra matched the characteristic data of the proposed triterpene skeleton. The compound was finally identified as 28-hydroxyfriedelan-3-one-29-oic acid on the basis of spectroscopic evidence, including two dimensional nuclear magnetic resona