a review of topical diclofenac use in musculoskeletal disease回顾局部双氯芬酸用于肌肉骨骼疾病.pdfVIP

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a review of topical diclofenac use in musculoskeletal disease回顾局部双氯芬酸用于肌肉骨骼疾病.pdf

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a review of topical diclofenac use in musculoskeletal disease回顾局部双氯芬酸用于肌肉骨骼疾病

Pharmaceuticals 2010, 3, 1892-1908; doi:10.3390/ph3061892 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review A Review of Topical Diclofenac Use in Musculoskeletal Disease Bindu Nair and Regina Taylor-Gjevre * Division of Rheumatology, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan S7N 0W8, Canada; E-Mail: Bindu.Nair@saskatoonhealthregion.ca (B.N.) * Author to whom correspondence should be addressed; E-Mail: r.gjevre@usask.ca; Tel.: +1-306-966-8271; Fax: +1-306-966-8381 Received: 22 April 2010; in revised form: 28 May 2010 / Accepted: 8 June 2010 / Published: 11 June 2010 Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medications for the treatment of musculoskeletal disorders. Osteoarthritis is the most common form of arthritis in humans and its prevalence rises with age. Oral NSAIDs have potential associated toxicities that must be monitored for and can limit the use of these drugs in certain populations including people of older age. Topical NSAIDs are now being recognized as an option for the treatment strategy of osteoarthritis. We review the efficacy and safety of one of the most common topical NSAIDS, topical diclofenac, for the treatment of osteoarthritis. Keywords: NSAIDs; musculoskeletal; osteoarthritis; diclofenac 1. Introduction Non-steroidal anti-inflammatory drugs (NSAIDs) are widely employed in musculoskeletal disease, both for their anti-infl