a pilot study of il-1 inhibition by anakinra in acute gout一个试点研究il - 1的抑制anakinra在急性痛风.pdfVIP

Available online /content/9/2/R28 Vol 9 No 2 Open Access Research article A pilot study of IL-1 inhibition by anakinra in acute gout 1 2 1 3 Alexander So , Thibaut De Smedt , Sylvie Revaz and Jürg Tschopp 1Service of Rhumatologie, Department of Medicine, Centre Hospitalier Universtaire Vaudois and University of Lausanne, 1011 Lausanne, Switzerland 2Apoxis SA, Avenue de Sévelin 18-20, 1004 Lausanne, Switzerland 3Institute of Biochemistry, University of Lausanne, chemin de Boveresses 155, 1066 Epalinges, Switzerland Corresponding author: Alexander So, AlexanderKai-Lik.So@chuv.ch Received: 13 Feb 2007 Revisions requested: 1 Mar 2007 Revisions received: 5 Mar 2007 Accepted: 12 Mar 2007 Published: 12 Mar 2007 Arthritis Research Therapy 2007, 9:R28 (doi:10.1186/ar2143) This article is online at: /content/9/2/R28 © 2007 So et al., licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Monosodium urate crystals stimulate monocytes and findings, we performed a pilot, open-labeled study (trial macrophages to release IL-1β through the NALP3 component registration number ISRCT in 10 patients with of the inflammasome. The effectiveness of IL-1 inhibition in gout who could not tolerate or had failed standard hereditary autoinflammatory syndromes with mutatio