a role for age-related changes in tgfβ signaling in aberrant chondrocyte differentiation and osteoarthritis与年龄相关的变化的作用tgfβ信号异常软骨细胞分化和骨关节炎.pdfVIP

van der Kraan et al. Arthritis Research Therapy 2010, 12:201 /content/12/1/201 R E V I E W A role for age-related changes in TGFβ signaling in aberrant chondrocyte dif erentiation and osteoarthritis Peter M van der Kraan*, Esmeralda N Blaney Davidson and Wim B van den Berg trigger, while secondary OA is the result of an evident Abstract underlying affliction. h e main features of this disease are Transforming growth factor beta (TGFβ) is a growth cartilage erosion, synovial fi brosis, osteophyte formation factor with many faces. In our osteoarthritis (OA) at the joint margins and sclerosis of the subchondral research we have found that TGFβ can be protective as bone. Patients with OA suff er from joint pain and tender- well as deleterious for articular cartilage. We postulate ness, occasional eff usions and, in the long run, loss of that the dual ef ects of TGFβ on chondrocytes can be joint function. explained by the fact that TGFβ can signal via dif erent h e etiology of primary OA is not known but several receptors and related Smad signaling routes. On risk factors have been detected. Systemic risk factors chondrocytes, TGFβ not only signals via the canonical include genetic background, ethnicity, gender and obesity, type I receptor ALK5 but also via the ALK1 receptor. but the main risk factor for the initiation and progression Notably, signaling via ALK5 (Smad2/3 route) results of primary OA is ageing. Functional articular cartilage is in markedly dif erent chondrocyte responses than